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Stearoyl Serotonin

CAT: 0804-HY-121465-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-121465-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Stearoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin. Arachidonoyl serotonin is a dual antagonist of fatty acid amide hydrolase (FAAH) and the transient receptor potential vanilloid-type 1 (TRPV1) channel, reducing both acute and chronic peripheral pain. The effects of replacing the arachidonoyl portion with the saturated 18-carbon stearoyl moiety have not been studied. However, replacement of arachidonate with saturated 11- or 12-carbon fatty acids produces compounds that potently inhibit capsaicin-induced TRPV1 channel activation (IC50=0.76 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 μM) .
CAS Number
67964-87-8
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/stearoyl-serotonin.html
Smiles
O=C(CCCCCCCCCCCCCCCCC)NCCC1=CNC2=CC=C(C=C12)O
Molecular Formula
C28H46N2O2
Molecular Weight
442.68
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Ortar, et al. New N-arachidonoylserotonin analogues with potential \"dual\" mechanism of action against pain. J. Med. Chem. 50 (26), 6554-6569 (2007) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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