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Norleual (TFA)

CAT: 0804-HY-P1415A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1415A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Norleual TFA, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF) /c-Met inhibitor with an IC50 of 3 pM. Norleual TFA is an AT4 receptor antagonist and exhibits potent antiangiogenic activities[1].
UNSPSC
12352209
Target
Angiotensin Receptor; c-Met/HGFR
Type
Peptides
Related Pathways
GPCR/G Protein; Protein Tyrosine Kinase/RTK
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/norleual-tfa.html
Purity
99.93
Solubility
H2O : ≥ 50 mg/mL
Smiles
O=C(N(CCC1)[C@@H]1C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)[C@@H](NC[C@H](CC(C)C)NC([C@@H](NC([C@@H](N)CCCC)=O)CC(C=C3)=CC=C3O)=O)CC4=CN=CN4.O=C(O)C(F)(F)F
Molecular Formula
C43H59F3N8O9
Molecular Weight
888.97
References & Citations
[1]B J Yamamoto, et al. The angiotensin IV analog Nle-Tyr-Leu-psi- (CH2-NH2) 3-4-His-Pro-Phe (norleual) can act as a hepatocyte growth factor/c-Met inhibitor. J Pharmacol Exp Ther. 2010 Apr;333 (1) :161-73.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported

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