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PDE11 rabbit pAb

CAT: 0855-ES14188-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES14188-01Size:50 µL
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Background
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Description
The 3', 5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3', 5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
UniProt
Q9HCR9
Swiss Prot
Q9HCR9
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human PDE11 AA range: 421-471
Target
PDE11
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm, cytosol .
Gene ID (Human)
50940

UniProtKB · Q9HCR9

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

PDE11_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9HCR9
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PDE11A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.4.35, 3.1.4.53
Processing
—
Secondary accessions
Q14CD1, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45
Protein keywords

Molecular function

Allosteric enzymeHydrolase

Coding sequence diversity

Alternative splicing

Ligand

cAMPcGMPMetal-binding

Disease

Cushing syndrome

Cellular component

Cytoplasm

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

Domain

Repeat

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