TH-263

CAT: 0804-HY-135843-03Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-135843-03Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

TH-263, a diaryl sulfonamide derivative, is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257[1].

CAS Number

313520-94-4

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

LIM Kinase (LIMK)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/th-263.html

Purity

99.0

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(NCC1=CC=CC=C1)C2=CC=C(S(=O)(NCC3=CC=CC=C3)=O)C=C2

Molecular Formula

C21H20N2O3S

Molecular Weight

380.46

Precautions

H302, H315, H319

References & Citations

[1]Manetti F. Recent advances in the rational design and development of LIM kinase inhibitors are not enough to enter clinical trials. Eur J Med Chem. 2018 Jul 15;155:445-458.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

N-benzyl-4-(benzylsulfamoyl)benzamide

CAS Number	313520-94-4
PubChem CID	4371240
IUPAC Name	N-benzyl-4-(benzylsulfamoyl)benzamide
Molecular Formula	C21H20N2O3S
Molecular Weight	380.5
XLogP	3.2
Topological Polar Surface Area	83.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	7
Heavy Atom Count	27
Formal Charge	0
Complexity	552

SMILES

C1=CC=C(C=C1)CNC(=O)C2=CC=C(C=C2)S(=O)(=O)NCC3=CC=CC=C3

InChI

InChI=1S/C21H20N2O3S/c24-21(22-15-17-7-3-1-4-8-17)19-11-13-20(14-12-19)27(25,26)23-16-18-9-5-2-6-10-18/h1-14,23H,15-16H2,(H,22,24)

InChIKey

QDGVJMITKNOVTP-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 313520-94-4

CID: 4371240

Formula: C21H20N2O3S

MW: 380.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	380.5
XLogP3	3.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	7
Exact Mass	380.11946368
Monoisotopic Mass	380.11946368
Topological Polar Surface Area	83.7 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	552
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-114270	JGK-263
HY-123019	RA-263
HY-168886	Anticancer agent 263
HY-W953261	CRBN ligand-263
HY-168478	Antibacterial agent 263
HY-146243-01	TH-Z835
HY-153663-01	TH-Z827
HY-122630-01	TH-257
HY-11054-01	TH-237A
HY-153662-01	TH-Z816

Alternative Products

Catalog	Name
MBS5756123	TH-263
NMA52094-01	TH 263
A22197-500	TH-263 500mg
A22197-50	TH-263 50mg
A22197-1	TH-263 1mg
A22197-100	TH-263 100mg
A22197-25	TH-263 25mg
A22197-200	TH-263 200mg
A22197-10	TH-263 10mg
A22197-5	TH-263 5mg

TH-263

Chemical Information

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