Gabapentin

Gabapentin

• CAS Number: 60142-96-3
• UNSPSC Description: Gabapentin is a potent, orally active P/Q type Ca2+ channel blocker. Gabapentin inhibits neuronal Ca2+ influx and reduction of neurotransmitter release. Gabapentin is a GABA analog that can be used to relieve neuropathic pain[1][2][3].
• Target Antigen: Calcium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/Gabapentin.html
• Purity: 98.0
• Solubility: DMSO : 1 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
• Smiles: O=C(O)CC1(CN)CCCCC1
• Molecular Weight: 171.24
• References & Citations: [1]Fink K, et, al. Inhibition of neuronal Ca(2+) influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices. Br J Pharmacol. 2000 Jun;130(4):900-6.|[2]Celikyurt IK, et, al. Gabapentin, A GABA analogue, enhances cognitive performance in mice. Neurosci Lett. 2011 Apr 1;492(2):124-8.|[3]Meymandi MS, et, al. Gabapentin action and interaction on the antinociceptive effect of morphine on visceral pain in mice. Eur J Anaesthesiol. 2008 Feb;25(2):129-34.ACS Pharmacol Transl Sci. 2023 Mar 6.|Cell Rep. 2019 Dec 17;29(12):3847-3858.e5.|iScience. 2023 Jun 27.|J Nat Med. 2021 Sep 12.|J Pain. 2019 May;20(5):577-591. |Pharmacol Res Perspect. 2021 Oct;9(5):e00879.|Sci Total Environ. 2022 Jul 10;829:154437.|Eur J Drug Metab Pharmacokinet. 2022 Jun 22.
• Shipping Conditions: Room Temperature
• Storage Conditions: Store at room temperature 3 years
• Clinical Information: Launched