Gabapentin

• Description :

  Gabapentin is a potent, orally active P/Q type Ca2+ channel blocker. Gabapentin inhibits neuronal Ca2+ influx and reduction of neurotransmitter release. Gabapentin is a GABA analog that can be used to relieve neuropathic pain[1][2][3].

• CAS Number :

  [60142-96-3]

• UNSPSC :

  12352211

• Hazard Statement :

  H315, H319, H335, H360

• Target :

  Calcium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Gabapentin.html

• Purity :

  99.49

• Solubility :

  DMSO : 1 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

• Smiles :

  O=C(O)CC1(CN)CCCCC1

• Molecular Formula :

  C9H17NO2

• Molecular Weight :

  171.24

• Precautions :

  H315, H319, H335, H360

• References & Citations :

  [1]Fink K, et, al. Inhibition of neuronal Ca (2+) influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices. Br J Pharmacol. 2000 Jun;130 (4) :900-6.|[2]Celikyurt IK, et, al. Gabapentin, A GABA analogue, enhances cognitive performance in mice. Neurosci Lett. 2011 Apr 1;492 (2) :124-8.|[3]Meymandi MS, et, al. Gabapentin action and interaction on the antinociceptive effect of morphine on visceral pain in mice. Eur J Anaesthesiol. 2008 Feb;25 (2) :129-34.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  Store at room temperature 3 years

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Citation 01 :

  ACS Pharmacol Transl Sci. 2023 Mar 6;6 (4) :519-525.|Br J Pharmacol. 2025 Aug 9.|Cell Rep. 2019 Dec 17;29 (12) :3847-3858.e5.|iScience. 2023 Jul 3;26 (8) :107264.|J Nat Med. 2022 Jan;76 (1) :268-275.|J Pain. 2019 May;20 (5) :577-591. |Mol Biol Rep. 2025 Sep 3;52 (1) :859.|Neuropharmacology. 2024 Dec 21:110276.|Pharmacol Res Perspect. 2021 Oct;9 (5) :e00879.|Sci Total Environ. 2022 Jul 10;829:154437.|Eur J Drug Metab Pharmacokinet. 2022 Sep;47 (5) :639-652.