Chlortetracycline-13C,d3 (hydrochloride)

Chlortetracycline-13C,d3 (hydrochloride)

• UNSPSC Description: Chlortetracycline-13C,d3 hydrochloride (7-Chlorotetracycline-13C,d3 hydrochloride) is the 13C- and deuterium labeled Chlortetracycline hydrochloride (HY-B1327). Chlortetracycline hydrochloride is an orally active, selective antibiotic, that inhibits methanogenic bacteria through inhibition of bacterial protein synthesis. Chlortetracycline hydrochloride is a specific and potent calcium ionophore antibiotic, that inhibits binding of aminoacyl-tRNA to ribosomes[1][2][3][4][5].
• Target Antigen: Antibiotic; Bacterial; Isotope-Labeled Compounds; Parasite
• Type: Reference compound
• Related Pathways: Anti-infection;Others
• Field of Research: Infection
• Smiles: O=C(N)C(C1=O)=C([C@H]([C@@]2(C[C@@]3([C@](O)(C4=C(C(O)=CC=C4Cl)C(C3=C([C@@]21O)O)=O)C)[H])[H])N(C)[13C]([2H])([2H])[2H])O.Cl
• Molecular Weight: 519.35
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Elmund GK, et al. Role of excreted chlortetracycline in modifying the decomposition process in feedlot waste. Bull Environ Contam Toxicol. 1971 Mar-Apr;6(2):129-32.|[3]Saling PM, et al. Mouse gamete interactions during fertilization in vitro. Chlortetracycline as a fluorescent probe for the mouse sperm acrosome reaction. J Cell Biol. 1979 Dec;83(3):544-55.|[4]Reyes-Contreras C, et al. Methanogenic toxicity evaluation of chlortetracycline hydrochloride[J]. Electronic Journal of Biotechnology, 2015, 18(6): 445-450.|[5]Liu D, et al. Synthesis and evaluation of bisulfate/mesylate-conjugated chlortetracycline with high solubility and bioavailability[J]. Acta Pharm. 2020 Dec 1;70(4):483-498.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported