Butenafine-13C,d3 (hydrochloride)

Butenafine-13C,d3 (hydrochloride)

• UNSPSC Description: Butenafine-13C,d3 (hydrochloride) is the 13C- and deuterium labeled. Butenafine Hydrochloride (KP363 Hydrochloride) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.
• Target Antigen: Antibiotic; Fungal; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Anti-infection;Others
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Solubility: 10 mM in DMSO
• Smiles: CC(C)(C)C(C=C1)=CC=C1CN([13C]([2H])([2H])[2H])CC2=CC=CC3=C2C=CC=C3.Cl
• Molecular Weight: 357.94
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.|[2]Butenafine|[3]Kokjohn K, Bradley M, Griffiths B, Ghannoum M. Evaluation of in vitro activity of ciclopirox olamine, butenafine HCl and econazole nitrate against dermatophytes, yeasts and bacteria. Int J Dermatol. 2003 Sep;42 Suppl 1:11-7.|[4]McNeely W, Spencer CM. Butenafine. Drugs. 1998 Mar;55(3):405-12; discussion 413.|[5]Singal A. Butenafine and superficial mycoses: current status. Expert Opin Drug Metab Toxicol. 2008 Jul;4(7):999-1005.|[6]Syed TA, Maibach HI. Butenafine hydrochloride: for the treatment of interdigital tinea pedis. Expert Opin Pharmacother. 2000 Mar;1(3):467-73.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported