OSM-S-106

CAT: 0804-HY-162238-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-162238-01Size:5 mg

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Description

OSM-S-106 is a pro-inhibitor and that inhibition of PfAsnRS occurs via enzyme-mediated production of an Asn-OSM-S-106 adduct. OSM-S-106 inhibits protein translation and activates the amino acid starvation response. OSM-S-106 exhibits selective activity against Plasmodium blood and liver stages and low intrinsic clearance by human microsomes[1].

CAS Number

2650846-59-4

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/osm-s-106.html

Purity

99.34

Solubility

10 mM in DMSO

Smiles

NC1=C2C(C=C(C3=CC(S(N)(=O)=O)=CC=C3)S2)=NC=N1

Molecular Formula

C12H10N4O2S2

Molecular Weight

306.36

References & Citations

[1]Xie SC, et al. Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Preprint. Res Sq. 2023; rs.3.rs-3198291. Published 2023 Jul 27.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

3-(4-Aminothieno[3,2-d]pyrimidin-6-yl)benzenesulfonamide

CAS Number	2650846-59-4
PubChem CID	44528665
IUPAC Name	3-(4-aminothieno[3,2-d]pyrimidin-6-yl)benzenesulfonamide
Molecular Formula	C12H10N4O2S2
Molecular Weight	306.4
XLogP	1.2
Topological Polar Surface Area	149
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	2
Heavy Atom Count	20
Formal Charge	0
Complexity	453

SMILES

C1=CC(=CC(=C1)S(=O)(=O)N)C2=CC3=C(S2)C(=NC=N3)N

InChI

InChI=1S/C12H10N4O2S2/c13-12-11-9(15-6-16-12)5-10(19-11)7-2-1-3-8(4-7)20(14,17)18/h1-6H,(H2,13,15,16)(H2,14,17,18)

InChIKey

MQMXDJVOZKMSNT-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2650846-59-4

CID: 44528665

Formula: C12H10N4O2S2

MW: 306.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	306.4
XLogP3	1.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	2
Exact Mass	306.02451792
Monoisotopic Mass	306.02451792
Topological Polar Surface Area	149 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	453
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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HY-113918	SW-106
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HY-114406-01	TD-106
HY-W324391-01	Coumarin 106
HY-124314	LEI-106
HY-W700297	K-106
HY-P991598	MOR-106
HY-117800-01	BJE6-106
HY-124618	FGI-106

Alternative Products

Catalog	Name
T87076-01	OSM-S-106
045-95	NSRP37 / prepro-Neuromedin S (70-106) (Human)
cyt-231-01	OSM
BA3082-25	MTR-106
T24734-01	RP-106
T69046-01	AK-106
T209428-01	EGFR-IN-106
T89954-01	LS-106
T87296-01	RC-106
PMC24938-01	BJE6-106

OSM-S-106

Chemical Information

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