LS-106

CAT: 931-T89954-01Size: 10 mgDry Ice: NoHazardous: No

10 mgSelected

PRICE

AVAILABILITY

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

1 / 1

Target

Apoptosis|||EGFR

Related Pathways

Angiogenesis|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Apoptosis

Bioactivity

LS-106 is an orally active, effective epidermal growth factor receptor (EGFR) inhibitor displaying antitumor activity both in vitro and in vivo. It inhibits the kinase activities of EGFR19del/T790M/C797S and EGFRL858R/T790M/C797S, with IC50 values of 2.4 nmol/L and 3.1 nmol/L, respectively, demonstrating stronger inhibition than Osimertinib. LS-106 induces cell apoptosis (Apoptosis), suppresses the proliferation of tumor cells carrying EGFR19del/T790M/C797S, and results in significant tumor reduction in a C797S mutant xenograft model.

Molecular Formula

C24H28BrClN5OP

Molecular Weight

548.84

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Related Products

Catalog	Name
T32897	LS 822
T32894	LS 105790
T69348-01	LS-104
T32899	LS-58500
T32896	LS 80707
T11879-01	LS-102
T27853-01	LS-008
T32895	LS 34
T76227-01	LS-BF1
T32898	LS 82-556

Alternative Products

Catalog	Name
HY-164490	LS-106
4081300	Hydra, LS
5311100	RNAisol LS
M38018-01	LS-102
297370	LS-Tetrasaccharide a
HY-135844-01	LS-102
MBS5777555	LS-008
MBS5818136	LS-BF1
BA7373-5.1	LS-102
4041700/24B	LS stem, LS root, Set/2

LS-106

Related Products

Alternative Products

Popular Products