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(R) -Odafosfamide

CAT: 0804-HY-124573-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124573-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R) -Odafosfamide (OBI-3424) is a proagent that is selectively converted by AKR1C3 (aldo-keto reductase 1C3) to a potent DNA-alkylating agent. (R) -Odafosfamide can be used for hepatocellular carcinoma, castrate-resistant prostate cancer, and acute lymphoblastic leukemia (ALL) research[1].
CAS Number
2097713-68-1
Product Name Alternative
OBI-3424; TH-3424; (R) -AST-3424
UNSPSC
12352005
Target
DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/obi-3424.html
Purity
98.52
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=P(N1CC1)(N2CC2)O[C@@H](C3=CC=C([N+]([O-])=O)C(OC4=CC=CC(C(N(C)C)=O)=C4)=C3)C
Molecular Formula
C21H25N4O6P
Molecular Weight
460.42
References & Citations
[1]Kathryn Evans, et al. OBI-3424, a Novel AKR1C3-Activated Prodrug, Exhibits Potent Efficacy against Preclinical Models of T-ALL. Clin Cancer Res. 2019 Jul 15;25 (14) :4493-4503.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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