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Odafosfamide

CAT: 0804-HY-149040Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149040Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Odafosfamide ((S) -OBI-3424) is a highly selective prodrug bis-alkylating agent activated by aldehyde-keto reductase 1C3 (AKR1C3 () . Odafosfamide is highly cytotoxic to cell lines with high AKR1C3 expression. Odafosfamide exhibits antitumor activity in a variety of tumors with high AKR1C3 expression (such as liver cancer, non-small cell lung cancer, and leukemia) . Odafosfamide can be used in cancer research[1][2].
CAS Number
2097713-69-2
Product Name Alternative
(S) -OBI-3424; (S) -TH-3424; AST-3424
UNSPSC
12352005
Target
17β-HSD
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
95.61
Smiles
C[C@@H](C1=CC(OC2=CC(C(N(C)C)=O)=CC=C2)=C(C=C1)[N+]([O-])=O)OP(N3CC3)(N4CC4)=O
Molecular Formula
C21H25N4O6P
Molecular Weight
460.42
References & Citations
[1]Meng F, et al. A novel selective AKR1C3-activated prodrug AST-3424/OBI-3424 exhibits broad anti-tumor activity. Am J Cancer Res. 2021 Jul 15;11 (7) :3645-3659.|[2]Evans K, et al. OBI-3424, a Novel AKR1C3-Activated Prodrug, Exhibits Potent Efficacy against Preclinical Models of T-ALL. Clin Cancer Res. 2019 Jul 15;25 (14) :4493-4503.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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