Citrullinated α-Enolase Human Recombinant

• Description:

  Citrullinated α-Enolase Human Recombinant_x000D_ Catalog number: B2018761_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 100 µg_x000D_ Molecular Weight or Concentration: 47.74 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -80°C_x000D_ Keywords: Enolase-1_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Titcombe PJ, Wigerblad G, Sippl N, Zhang N, Shmagel AK, Sahlström P, Zhang Y, Barsness LO, Ghodke-Puranik Y, Baharpoor A, Hansson M, Israelsson L, Skriner K, Niewold TB, Klareskog L, Svensson CI, Amara K, Malmström V, Mueller DL. Pathogenic Citrulline-Multispecific B Cell Receptor Clades in Rheumatoid Arthritis Arthritis Rheumatol. 2018 Dec;70(12):1933-1945._x000D_ 2: Lundberg K, Kinloch A, Fisher BA, Wegner N, Wait R, Charles P, Mikuls TR, Venables PJ. Antibodies to citrullinated alpha-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase Arthritis Rheum. 2008 Oct;58(10):3009-19._x000D_ 3: Damgaard D, Bawadekar M, Senolt L, Stensballe A, Shelef MA, Nielsen CH. Relative efficiencies of peptidylarginine deiminase 2 and 4 in generating target sites for anti-citrullinated protein antibodies in fibrinogen, alpha-enolase and histone H3 PLoS One. 2018 Aug 30;13(8):e0203214._x000D_ 4: Kinloch AJ, Alzabin S, Brintnell W, Wilson E, Barra L, Wegner N, Bell DA, Cairns E, Venables PJ. Immunization with Porphyromonas gingivalis enolase induces autoimmunity to mammalian α-enolase and arthritis in DR4-IE-transgenic mice Arthritis Rheum. 2011 Dec;63(12):3818-23._x000D_ 5: Tan YC, Kongpachith S, Blum LK, Ju CH, Lahey LJ, Lu DR, Cai X, Wagner CA, Lindstrom TM, Sokolove J, Robinson WH. Barcode-enabled sequencing of plasmablast antibody repertoires in rheumatoid arthritis Arthritis Rheumatol. 2014 Oct;66(10):2706-15._x000D_ 6: Guillou C, Derambure C, Fréret M, Verdet M, Avenel G, Golinski ML, Sabourin JC, Le Loarer F, Adriouch S, Boyer O, Lequerré T, Vittecoq O. Prophylactic Injection of Recombinant Alpha-Enolase Reduces Arthritis Severity in the Collagen-Induced Arthritis Mice Model PLoS One. 2015 Aug 24;10(8):e0136359._x000D_ 7: Tajerian M, Hung V, Khan H, Lahey LJ, Sun Y, Birklein F, Krämer HH, Robinson WH, Kingery WS, Clark JD. Identification of KRT16 as a target of an autoantibody response in complex regional pain syndrome Exp Neurol. 2017 Jan;287(Pt 1):14-20._x000D_ 8: Jang B, Jeon YC, Choi JK, Park M, Kim JI, Ishigami A, Maruyama N, Carp RI, Kim YS, Choi EK. Peptidylarginine deiminase modulates the physiological roles of enolase via citrullination: links between altered multifunction of enolase and neurodegenerative diseases Biochem J. 2012 Jul 15;445(2):183-92._x000D_ 9: Lundberg K, Wegner N, Yucel-Lindberg T, Venables PJ. Periodontitis in RA-the citrullinated enolase connection Nat Rev Rheumatol. 2010 Dec;6(12):727-30._x000D_ 10: Cook K, Daniels I, Symonds P, Pitt T, Gijon M, Xue W, Metheringham R, Durrant L, Brentville V. Citrullinated α-enolase is an effective target for anti-cancer immunity Oncoimmunology. 2017 Nov 6;7(2):e1390642. _x000D_ _x000D_ Products Related to Citrullinated α-Enolase Human Recombinant can be found at Proteins

• Short Description:

  Catalog Number: B2018761 (100 µg)_x000D_ Citrullinated α-Enolase (human, recombinant) is a protein that has been modified to contain citrulline residues. Citrullination is a post-translational modification where the amino acid arginine is converted to citrulline. This modified form of α-Enolase is often used in research studies to investigate autoimmune diseases such as rheumatoid arthritis, where citrullinated proteins are known to play a role in the immune response. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3