Cn2 toxin (TFA)

• Description :

  Cn2 toxin TFA (β-Mammal toxin Cn2 TFA) is a single-chain β-scorpion neurotoxic peptide that is the main toxin in scorpion venom. Cn2 toxin (TFA) specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6[1].

• Product Name Alternative :

  β-Mammal toxin Cn2 (TFA)

• UNSPSC :

  12352209

• Target :

  Sodium Channel

• Type :

  Peptides

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/cn2-toxin-tfa.html

• Purity :

  98.13

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C([C@@H](N)CCCCN)N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NC(C(NC(C(NC(C(NC(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(NCC(N[C@H](C(NCC(NCC(N[C@H]1CC2=CC=C(O)C=C2)=O)=O)=O)C)=O)=O)CCCCN)=O)=O)CC3=CC=C(O)C=C3)=O)CCC(N)=O)=O)CCC(N)=O)=O)CCCCN)=O)CSSC[C@H](NC4=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N5[C@H](C(N[C@H](C(N6[C@H](C(N[C@H](C(N[C@H](C(N[C@H]7CCCNC(N)=N)=O)CCCCN)=O)CC(N)=O)=O)CCC6)=O)CC(C)C)=O)CCC5)=O)CC8=CNC9=CC=CC=C89)=O)C(C)C)=O)[C@H](CC)C)=O)C)=O)CCC(N)=O)=O)CCC(O)=O)=O)CC%10=CC=C(O)C=C%10)=O)CC(C)C)=O)CC%11=CNC=N%11)=O)[C@@H](C)O)=O)=O)CCC(O)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)CSSCC(NC%12=O)C(N[C@H]4CC%13=CNC%14=CC=CC=C%13%14)=O)=O)CC%15=CC=C(O)C=C%15)=O)CC(O)=O)=O)CC(N)=O)=O)CC(O)=O)=O)=O)CC(C)C)=O)CCCCN)=O)CC(C)C)=O)CSSC[C@H](NC1=O)C(NC(C(NC(C(NC(C(NC%12C)=O)CC%16=CC=CC=C%16)=O)C)=O)CC%17=CC=C(O)C=C%17)=O)=O)CCC(O)=O)=O)CC%18=CC=C(O)C=C%18)=O)CCCCN)=O)CSSC[C@H](NC7=O)C(N[C@H](C(N)=O)CO)=O)=O)=O)[C@@H](C)O)=O)CC(N)=O)=O)CCCCN)=O)CC(O)=O)=O)C(C)C)=O)CC(C)C)=O)CC%19=CC=C(O)C=C%19)=O)=O)CCC(O)=O.xOC(C(F)(F)F)=O

• Molecular Formula :

  C336H496N90O96S8.xC2HF3O2

• Molecular Weight :

  7588.60 (free base)

• References & Citations :

  [1]Chen R, et al. Conserved functional surface of antimammalian scorpion β-toxins. J Phys Chem B. 2012 Apr 26;116 (16) :4796-800.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported