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Vm24-toxin TFA

CAT: 0013-GTR19145224-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19145224-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vm24-toxin (Vaejovis mexicanus peptide 24) TFA is a peptide composed of 36 amino acids, known for effectively and selectively blocking Kv1.3 channels, exhibiting an affinity (Kd) of approximately 3 pM in lymphocytes. It demonstrates over 1500 times greater affinity for Kv1.3 compared to other tested potassium channels. The structure of Vm24-toxin TFA includes a twisted cystine-stabilized α/β motif, comprising a single-turn α-helix and a three-stranded antiparallel β-sheet, stabilized by four disulfide bridges. Additionally, Vm24-toxin TFA can attenuate the response of CD4+ effector memory T cells to T-cell receptor (TCR) stimulation.
Field of Research
Infectious Disease & Virology; Immunology & Inflammation, Pharmacology & Drug Discovery
Storage Conditions
-20°C
Notes
For research use only.

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