USP7-IN-3

• Description :

  USP7-IN-3 (Compound 5) is an effective and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7) . USP7-IN-3 can be used for research on acute lymphoblastic leukemia[1].

• CAS Number :

  [2202738-42-7]

• UNSPSC :

  12352005

• Target :

  Deubiquitinase; MDM-2/p53

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/USP7-IN-3.html

• Purity :

  99.06

• Solubility :

  DMSO : 90 mg/mL (ultrasonic)

• Smiles :

  O=C(N1CCC(CN2C(C3=NN(C)C(C4=CC=C(CN)C=C4)=C3N=C2)=O)(O)CC1)C[C@@H](C(F)(F)F)C5=CC=CC=C5

• Molecular Formula :

  C29H31F3N6O3

• Molecular Weight :

  568.59

• References & Citations :

  [1]Gavory G, et al. Discovery and characterization of highly potent and selective allosteric USP7 inhibitors. Nat Chem Biol. 2018 Feb;14 (2) :118-125.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported