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Estriol-d3

CAT: 0804-HY-B0412S2Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0412S2Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Estriol-d3 is the deuterium labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.
CAS Number
[79037-36-8]
UNSPSC
12352005
Hazard Statement
H351, H360, H362, H410
Target
Endogenous Metabolite; Estrogen Receptor/ERR; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Purity
97.57
Solubility
DMSO : 250mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
C[C@@]12[C@](C[C@H]([C@]2([2H])O)O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC([2H])=C(O)C([2H])=C4CC3
Molecular Formula
C18H21D3O3
Molecular Weight
291.40
Precautions
H351, H360, H362, H410
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Morinaga, A., et al., Effects of sex hormones on Alzheimer's disease-associated beta-amyloid oligomer formation in vitro. Exp Neurol, 2011. 228 (2) : p. 298-302.|[3]Begum, M., et al., Neonatal estrogenic exposure suppresses PTEN-related endometrial carcinogenesis in recombinant mice. Lab Invest, 2006. 86 (3) : p. 286-96.|[4]Hewitt, S.C. and K.S. Korach, Estrogenic activity of bisphenol A and 2,2-bis (p-hydroxyphenyl) -1,1,1-trichloroethane (HPTE) demonstrated in mouse uterine gene profiles. Environ Health Perspect, 2011. 119 (1) : p. 63-70.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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