Antitumor agent-139

• UNSPSC Description:

  Antitumor agent-139 (compound 9b) is a liver - and mitochondria-targeting gold(I) complexe, and produces reactive oxygen species (ROS) and facilitates DNA excretion. Antitumor agent-139 inhibits tumor growth in a patient-derived xenograft model of hepatocellular carcinoma[1].

• Target Antigen:

  Reactive Oxygen Species

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/antitumor-agent-139.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@](CC[C@@]1([C@]2(C[C@](C)(CC1)C(OCC#C[Au]C3N(C=CN3CC)CC)=O)[H])C)([C@@]4(CCC5C(C)([C@H](CC[C@@]5(C46)C)OC(CCCCC[P+](C7=CC=CC=C7)(C8=CC=CC=C8)C9=CC=CC=C9)=O)C)C)C2=CC6=O.[Br-]

• Molecular Weight:

  1269.21

• References & Citations:

  [1]Li F, et al. Simultaneous Activation of Immunogenic Cell Death and cGAS-STING Pathway by Liver- and Mitochondria-Targeted Gold(I) Complexes for Chemoimmunotherapy of Hepatocellular Carcinoma. J Med Chem. 2024 Feb 8;67(3):1982-2003.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  9007-83-4