FX-11

• Description:

  FX-11 is a potent, selective, reversible and competitive lactate dehydrogenase A (LDHA) inhibitor, with a Ki of 8 μM. FX-11 reduces ATP levels and induces oxidative stress, ROS production and cell death. FX-11 shows antitumor activity in lymphoma and pancreatic cancer xenografts[1][2][3].

• Product Name Alternative:

  LDHA Inhibitor FX11

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319

• Target:

  Apoptosis; Lactate Dehydrogenase; Reactive Oxygen Species (ROS)

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/FX-11.html

• Purity:

  99.21

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  O=C (C1=C2C=C (CC3=CC=CC=C3) C (C) =CC2=C (CCC) C (O) =C1O) O

• Molecular Formula:

  C22H22O4

• Molecular Weight:

  350.41

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]EC Calvaresi. Small molecule inhibitors of lactate dehydrogenase a as an anticancer strategy. 2014.|[2]Le A, et, al. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci U S A. 2010 Feb 2;107 (5) :2037-42.|[3]Mohammad GH, et al. Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer. Cancers (Basel) . 2019 Sep 16;11 (9) :1372.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  LDHA

• CAS Number:

  213971-34-7