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BCL6-IN-11

CAT: 0804-HY-177756Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-177756Size:1 Each
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Description
BCL6-IN-11 (Compound 8) is an efficient inhibitor that induces partial degradation of BCL6 with its IC50 value for inhibiting the interaction between BCL6 and its co-inhibitory proteins (such as NCOR1) of 6 nM. BCL6-IN-11 can induce approximately 52% degradation of BCL6 after being treated with 5 μM concentration for 90 minutes, and thus is also classified as a partial degrader. BCL6-IN-11 can be used for the study of lymphoma[1].
CAS Number
2230406-60-5
UNSPSC
12352005
Target
BCL6
Related Pathways
Immunology/Inflammation
Field of Research
Cancer
Smiles
CNC(COC1=CC2=CC(NC3=NC(N4CCC(CC4)Cl)=NC=C3Cl)=CC=C2N(C1=O)C)=O
Molecular Formula
C22H24Cl2N6O3
Molecular Weight
491.37
References & Citations
[1]Kerres N, et al. Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6. Cell Rep. 2017 Sep 19;20 (12) :2860-2875.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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