BCL6-IN-11

• Description:

  BCL6-IN-11 (Compound 8) is an efficient inhibitor that induces partial degradation of BCL6 with its IC50 value for inhibiting the interaction between BCL6 and its co-inhibitory proteins (such as NCOR1) of 6 nM. BCL6-IN-11 can induce approximately 52% degradation of BCL6 after being treated with 5 μM concentration for 90 minutes, and thus is also classified as a partial degrader. BCL6-IN-11 can be used for the study of lymphoma[1].

• UNSPSC:

  12352005

• Target:

  BCL6

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Cancer

• Smiles:

  CNC(COC1=CC2=CC(NC3=NC(N4CCC(CC4)Cl)=NC=C3Cl)=CC=C2N(C1=O)C)=O

• Molecular Formula:

  C22H24Cl2N6O3

• Molecular Weight:

  491.37

• References & Citations:

  [1]Kerres N, et al. Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6. Cell Rep. 2017 Sep 19;20 (12) :2860-2875.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2230406-60-5]