DIDS

• Description :

  DIDS is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits RAD51, inhibiting RAD51-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research[1][2][3][4].

• Product Name Alternative :

  MDL101114ZA (free base)

• UNSPSC :

  12352005

• Hazard Statement :

  H315-H319-H335

• Target :

  RAD51; VDAC

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/dids.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=S(C1=CC(N=C=S)=CC=C1/C=C/C2=CC=C(C=C2S(=O)(O)=O)N=C=S)(O)=O

• Molecular Formula :

  C16H10N2O6S4

• Molecular Weight :

  454.52

• Precautions :

  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Ishida T, et, al. DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange. Nucleic Acids Res. 2009 Jun;37 (10) :3367-76.|[2]Lepke S, et, al. A study of the relationship between inhibition of anion exchange and binding to the red blood cell membrane of 4,4'-diisothiocyano stilbene-2,2'-disulfonic acid (DIDS) and its dihydro derivative (H2DIDS) . J Membr Biol. 1976 Oct 20;29 (1-2) :147-77.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  VDAC1

• Citation 01 :

  Cell Death Discov. 2023 Jul 8;9 (1) :234.|Adv Sci (Weinh) . 2021 Nov;8 (21) :e2101936.|Autophagy. 2021 Nov;17 (11) :3592-3606.|Biochem Biophys Res Commun. 2021 Jun 30:560:52-58.|bioRxiv. 2023 Jul 3.|bioRxiv. 2024 July 10.|Br J Pharmacol. 2025 Aug;182 (16) :3923-3951.|Cancer Sci. 2020 Nov;111 (11) :4288-4302.|Cell Death Dis. 2024 Nov 9;15 (11) :811.|CNS Neurosci Ther. 2025 Apr;31 (4) :e70410.|FEBS Open Bio. 2022 Feb;12 (2) :516-522.|Front Pharmacol. 2023 Jun 26:14:1191692. |J Cell Mol Med. 2021 Jun;25 (11) :5238-5249.|Life Sci. 2020 Oct 15;259:118390.|Phytomedicine. 2024 May 28:130:155785.|Proc Natl Acad Sci U S A. 2025 Oct 7;122 (40) :e2502841122.|Sci Total Environ. 2024 Jun 30:946:174246.|SSRN. 2023 Nov 14.|Virulence. 2025 Dec;16 (1) :2490208.

• CAS Number :

  [53005-05-3]