MMAE-d8

CAT: 0804-HY-15162A-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15162A-01Size:1 mg
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Description
MMAE-d8 is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor.
CAS Number
[2070009-72-0]
Product Name Alternative
Monomethyl auristatin E-d8; Deuterated labeled MMAE
UNSPSC
12352005
Hazard Statement
H300+H330, H340, H360, H370, H372, H412
Target
ADC Payload; Microtubule/Tubulin
Type
Isotope-Labeled Compounds
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.29
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N1[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)CCC1)=O)C)[C@@]([2H])(NC([C@@H](NC)C(C)C)=O)C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H]
Molecular Formula
C39H59D8N5O7
Molecular Weight
726.03
Precautions
H300+H330, H340, H360, H370, H372, H412
References & Citations
[1]Li F, et al. Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models. Cancer Res. 2016 May 1;76 (9) :2710-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
Auristatin

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