MMAE-d8

• Description :

  MMAE-d8 is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor.

• Product Name Alternative :

  Monomethyl auristatin E-d8; Deuterated labeled MMAE

• UNSPSC :

  12352005

• Hazard Statement :

  H300+H330, H340, H360, H370, H372, H412

• Target :

  ADC Payload; Microtubule/Tubulin

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Purity :

  99.29

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N1[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)CCC1)=O)C)[C@@]([2H])(NC([C@@H](NC)C(C)C)=O)C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H]

• Molecular Formula :

  C39H59D8N5O7

• Molecular Weight :

  726.03

• Precautions :

  H300+H330, H340, H360, H370, H372, H412

• References & Citations :

  [1]Li F, et al. Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models. Cancer Res. 2016 May 1;76 (9) :2710-9.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• Isoform :

  Auristatin

• CAS Number :

  [2070009-72-0]