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LX15B rabbit pAb

CAT: 0855-ES15076-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES15076-01Size:50 µL
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Background
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Description
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],
UniProt
O15296
Swiss Prot
O15296
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human LX15B AA range: 576-626
Target
LX15B
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
[Isoform A]: Nucleus . Other isoforms are excluded from the nucleus. .; Cytoplasm, cytosol . Cell membrane . Cytoplasm, cytoskeleton . Membrane ; Peripheral membrane protein . Cell junction, adherens junction . Cell junction, focal adhesion . Predominantly cytosolic; becomes enriched at membranes upon calcium binding. .
Gene ID (Human)
247

UniProtKB · O15296

Polyunsaturated fatty acid lipoxygenase ALOX15B

LX15B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O15296
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ALOX15B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
D3DTR2, Q8IYQ2, Q8TEV3, Q8TEV4, Q8TEV5, Q8TEV6, Q9UKM4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumIronLipid-bindingMetal-binding

Cellular component

Cell junctionCell membraneCytoplasmCytoskeletonMembraneNucleus

Molecular function

DioxygenaseOxidoreductase

Biological process

Lipid metabolism

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