GW-1100

CAT: 0804-HY-50691-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-50691-01Size:5 mg
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Description
GW-1100 is a selective GPR40 antagonist with a pIC50 of 6.9.
CAS Number
[306974-70-9]
UNSPSC
12352005
Target
Free Fatty Acid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/gw-1100.html
Purity
97.14
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C(CC2=CN=C(N=C2)OCC)=CN(C(SCC3=CC=C(C=C3)F)=N1)C4=CC=C(C(OCC)=O)C=C4
Molecular Formula
C27H25FN4O4S
Molecular Weight
520.58
References & Citations
[1]Stoddart LA, et al. Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O- (3-[35S]thio) triphosphate binding studies reflects binding of an endogenous agonist. Mol Pharmacol. 2007 Apr;71 (|[2]Briscoe CP, et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br J Pharmacol. 2006 Jul;148 (5) :619-28.|[3]Manosalva C, et al. Cloning, identification and functional characterization of bovine free fatty acid receptor-1 (FFAR1/GPR40) in neutrophils. PLoS One. 2015 Mar 19;10 (3) :e0119715.|[4]Nakamoto K, et al. Hypothalamic GPR40 signaling activated by free long chain fatty acids suppresses CFA-induced inflammatorychronic pain. PLoS One. 2013 Dec 12;8 (12) :e81563.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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