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NSC 228155

CAT: 0804-HY-101084-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101084-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NSC 228155 is an activator of EGFR, binds to the extracellular region of EGFR and enhance tyrosine phosphorylation of EGFR[1]. NSC 228155 is also a potent inhibitor of KIX-KID interaction, inhibits kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, with an IC50 of 0.36 μM[2].
CAS Number
113104-25-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
EGFR; Epigenetic Reader Domain; Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NSC_228155.html
Purity
98.0
Solubility
DMSO : 16 mg/mL (ultrasonic)
Smiles
[O-][N+]1=CC=CC=C1SC2=CC=C([N+]([O-])=O)C3=NON=C32
Molecular Formula
C11H6N4O4S
Molecular Weight
290.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Sakanyan V, et al. Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1. Sci Rep. 2016 Feb 17;6:21088.|[2]Xie F, et al. Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription. Bioorg Med Chem Lett. 2013 Oct 1;23 (19) :5371-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300; EGFR/ErbB1/HER1

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Alternative Products

CatalogName
NEA10425-01NSC 228155
A16638-10NSC 228155 10mg
A16638-200NSC 228155 200mg
A16638-100NSC 228155 100mg
A16638-50NSC 228155 50mg
A16638-25NSC 228155 25mg
A16638-5NSC 228155 5mg
A16638-10mM-DNSC 228155 10mM * 1mL in DMSO

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