Products for Research Use Only
RegisterLogin

DBET57

CAT: 0804-HY-123844-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-123844-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
DBET57 is an effective and selective BRD4BD1 degrader based on PROTAC technology, with the ability to induce cell apoptosis and anti-tumor activity. dBET57 mediates the recruitment of the E3 ubiquitin ligase CRL4Cereblon, showing a DC50/5h value of 500 nM for BRD4BD1[1][2].
CAS Number
1883863-52-2
UNSPSC
12352005
Hazard Statement
H302, H312, H315, H319, H332, H335
Target
Apoptosis; Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; PROTAC
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dbet57.html
Purity
99.94
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)C[C@H]4C5=NN=C(C)N5C6=C(C(C)=C(C)S6)C(C7=CC=C(Cl)C=C7)=N4
Molecular Formula
C34H31ClN8O5S
Molecular Weight
699.18
Precautions
H302, H312, H315, H319, H332, H335
References & Citations
[1]Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018 Jul;14 (7) :706-714.|[2]Si-Qi Jia, et al. The BRD4 Inhibitor dBET57 Exerts Anticancer Effects by Targeting Superenhancer-Related Genes in Neuroblastoma. J Immunol Res. 2022 Nov 16:2022:7945884.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4

Related Products

CatalogName
HY-123911-01DBET23
HY-112588-01DBET6
HY-101838-01DBET1
HY-173255DAO-dBET1
HY-173256Hyp-dBET1
HY-173257Cath-L-dBET1
HY-RS16414DBET Human Pre-designed siRNA Set A

Alternative Products

CatalogName
BA4688-10dBET57
A19133-500DBET57 500mg
A19133-5DBET57 5mg
A19133-100DBET57 100mg
A19133-50DBET57 50mg
A19133-10DBET57 10mg
A19133-1DBET57 1mg
A19133-25DBET57 25mg
A19133-10mM-DDBET57 10mM * 1mL in DMSO

Popular Products