L-DABA (hydrobromide)

• Description:

  L-DABA (L-2,4-Diaminobutyric acid) hydrobromide is a week GABA transaminase inhibitor with an IC50 of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.

• Product Name Alternative:

  L-2,4-Diaminobutyric acid (hydrobromide)

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Endogenous Metabolite; GABA Receptor

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/l-daba-hydrobromide.html

• Purity:

  98.0

• Solubility:

  DMSO : 23 mg/mL (ultrasonic)

• Smiles:

  NCC[C@H](N)C(O)=O.[H]Br

• Molecular Formula:

  C4H11BrN2O2

• Molecular Weight:

  199.05

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Ronquist G, et al. Antitumor activity of L-2,4 diaminobuturic acid against mouse fibrosarcoma cells in vitro and in vivo. J Cancer Res Clin Oncol. 1980;96 (3) :259-68.|[2]Beart PM, et al. l-2,4-Diaminobutyric acid and the GABA system. Neurosci Lett. 1977 Jul;5 (3-4) :193-8.|[3]Panasci L, et al. The cytolytic effect of L-2,4 diaminobutyric acid with malignant glioma cells and fibroblasts. Cancer Chemother Pharmacol. 1988;21 (2) :143-4.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [73143-97-2]