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BQ-123

CAT: 0013-GTR19163734-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163734-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BQ-123 (PMZ 2123) is a potent, selective, non-competitive cyclic pentapeptide ETA receptor antagonist with IC50 of 7.3 nM; antagonizes endothelin-1-induced contractions in rabbit aorta, increases in inositol phosphates in cultured rat vascular smooth muscle A10 cells, shifts concentration-response curves in isolated rabbit aorta elicited by angiotensin II, but does not bind to angiotensin II receptors nor affect angiotensin II-induced increases in inositol phosphates.Diabetes Phase 1 Clinical (In Vivo) :Sustained infusions of BQ-123 (0.16-164 nmol/kg per min, intravenously, for 6 h) produces dose-dependent reductions in mean arterial pressure in spontaneously hypertensive rats (SHR), the maximal reduction being obtained with a dose of 16 nmol/kg per min.BQ-123 (3 mg/kg; i.v.; given 15 minutes before pentylenetetrazole (PTZ) ) impedes the formation and spread of seizure to a great degree in PTZ (50 mg/kg; i.p.) +BQ-123 groups.
CAS Number
136553-81-6
Product Name Alternative
PMZ 2123 | BQ123
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 34 mg/mL
Smiles
O=C (O) C[C@H]1NC ([C@@H] (CC2=CNC3=C2C=CC=C3) NC ([C@H] (CC (C) C) NC ([C@@H] (C (C) C) NC ([C@@] (CCC4) ([H]) N4C1=O) =O) =O) =O) =O
Molecular Formula
C31H42N6O7
Molecular Weight
610.7012
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Cyclo (D-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl)

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