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THR-123

CAT: 0804-HY-P11354Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P11354Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
THR-123 is an orally active ALK3 peptide agonist. THR-123 has a relatively weak binding to ALK2, but does not bind to ALK6. THR-123 suppresses inflammation, apoptosis and the epithelial-to-mesenchymal transition program and reverses established fibrosis in five mouse models of acute and chronic renal injury. THR-123 can be used for the study of kidney fibrosis[1].
UNSPSC
12352209
Target
Apoptosis; Cadherin; Integrin; Interleukin Related; TGF-β Receptor
Related Pathways
Apoptosis; Cytoskeleton; Immunology/Inflammation; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@H]3CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)NC3=O)N
Molecular Formula
C83H124N22O27S2
Molecular Weight
1926.13
References & Citations
[1]Sugimoto H, et al. Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis. Nat Med. 2012 Feb 5;18 (3) :396-404.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
ALK3; IL-6; IL-8

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