Ethaverine (hydrochloride)

• UNSPSC Description:

  Ethaverine hydrochloride, a derivative of papaverine, inhibits cardiac L-type calcium channel. Ethaverine hydrochloride is a peripheral vasodilator and antispasmodic agent. Ethaverine hydrochloride can be used for research of peripheral vascular disease[1][2][3].

• Target Antigen:

  Calcium Channel; Monoamine Oxidase

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/ethaverine-hydrochloride.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCOC1=CC2=C(C=C1OCC)C=CN=C2CC3=CC=C(OCC)C(OCC)=C3.[H]Cl

• Molecular Weight:

  431.95

• References & Citations:

  [1]Wang Y, et al. Ethaverine, a derivative of papaverine, inhibits cardiac L-type calcium channels. Mol Pharmacol. 1991 Nov;40(5):750-5. |[2]Suh BC, et al. Inhibition by ethaverine of catecholamine secretion through blocking L-type Ca2+ channels in PC12 cells. Biochem Pharmacol. 1994 Mar 29;47(7):1262-6. |[3]Shin JS, et al. Inhibitory effects of ethaverine, a homologue of papaverine, on dopamine content in PC12 cells. Biol Pharm Bull. 2001 Jan;24(1):103-5. |[4]Prazma J, et al. Effect of ethaverine hydrochloride on cochlear microcirculation. Arch Otolaryngol. 1981 Apr;107(4):227-9. |[5]Lacroix P, et al. [Comparative activity of ethaverine and papaverine on chronotropic and dromotropic cardiac functions in the anesthetized dog]. Arch Int Pharmacodyn Ther. 1976 May;221(1):163-76. French. |[6]Lee SS, et al. Inhibitory effects of ethaverine, a homologue of papaverine, on monoamine oxidase activity in mouse brain. Biol Pharm Bull. 2001 Jul;24(7):838-40.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  985-13-7