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Ethaverine (hydrochloride)

CAT: 0804-HY-B1440-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1440-01Size:5 mg
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Description
Ethaverine hydrochloride, a derivative of papaverine, inhibits cardiac L-type calcium channel. Ethaverine hydrochloride is a peripheral vasodilator and antispasmodic agent. Ethaverine hydrochloride can be used for research of peripheral vascular disease[1][2][3].
CAS Number
985-13-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Calcium Channel; Monoamine Oxidase
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ethaverine-hydrochloride.html
Purity
99.72
Solubility
10 mM in DMSO
Smiles
CCOC1=CC2=C(C=C1OCC)C=CN=C2CC3=CC=C(OCC)C(OCC)=C3.[H]Cl
Molecular Formula
C24H30ClNO4
Molecular Weight
431.95
Precautions
H302, H315, H319, H335
References & Citations
[1]Wang Y, et al. Ethaverine, a derivative of papaverine, inhibits cardiac L-type calcium channels. Mol Pharmacol. 1991 Nov;40 (5) :750-5. |[2]Suh BC, et al. Inhibition by ethaverine of catecholamine secretion through blocking L-type Ca2+ channels in PC12 cells. Biochem Pharmacol. 1994 Mar 29;47 (7) :1262-6. |[3]Shin JS, et al. Inhibitory effects of ethaverine, a homologue of papaverine, on dopamine content in PC12 cells. Biol Pharm Bull. 2001 Jan;24 (1) :103-5. |[4]Prazma J, et al. Effect of ethaverine hydrochloride on cochlear microcirculation. Arch Otolaryngol. 1981 Apr;107 (4) :227-9. |[5]Lacroix P, et al. [Comparative activity of ethaverine and papaverine on chronotropic and dromotropic cardiac functions in the anesthetized dog]. Arch Int Pharmacodyn Ther. 1976 May;221 (1) :163-76. French. |[6]Lee SS, et al. Inhibitory effects of ethaverine, a homologue of papaverine, on monoamine oxidase activity in mouse brain. Biol Pharm Bull. 2001 Jul;24 (7) :838-40.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported