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Silperisone (hydrochloride)

CAT: 0804-HY-127004-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-127004-01Size:1 mg
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Description
Silperisone hydrochloride is an organosilicone compound similar to tolperisone that has centrally acting muscle relaxant properties. Silperisone (hydrochloride) is a sodium channel protein type 2 alpha channel blocker that blocks sodium and calcium channels in cells, reduces muscle cell excitability and contraction, reduces peripheral tone, and acts as a muscle relaxant and peripheral vascular dilator. Silperisone (hydrochloride) is used to study recurrent painful myoclonus due to spinal cord injury, abnormal hypertonia due to cerebrovascular disease, myotonia symptoms, pyramidal tonia syndrome, multiple sclerosis myospasm, and myelitis[1][2][3].
CAS Number
140944-30-5
Product Name Alternative
RGH-5002
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/silperisone-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(C[Si](C)(CN2CCCCC2)C)C=C1.Cl
Molecular Formula
C15H25ClFNSi
Molecular Weight
301.90
References & Citations
[1]Farkas S, et al. Simple pharmacological test battery to assess efficacy and side effect profile of centrally acting muscle relaxant drugs[J]. Journal of Pharmacological and Toxicological methods, 2005, 52 (2) : 264-273.|[2]Kocsis P, et al. Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels[J]. Journal of Pharmacology and Experimental Therapeutics, 2005, 315 (3) : 1237-1246.|[3]Farkas S, et al. Silperisone: a centrally acting muscle relaxant[J]. CNS Drug Reviews, 2006, 12 (3‐4) : 218-235.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

Chemical Information

Silperisone hydrochloride
CAS Number140944-30-5
PubChem CID178567
IUPAC Name(4-fluorophenyl)methyl-dimethyl-(piperidin-1-ylmethyl)silane;hydrochloride
Molecular FormulaC15H25ClFNSi
Molecular Weight301.90
Topological Polar Surface Area3.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Heavy Atom Count19
Formal Charge0
Complexity243
SMILES
C[Si](C)(CC1=CC=C(C=C1)F)CN2CCCCC2.Cl
InChI
InChI=1S/C15H24FNSi.ClH/c1-18(2,13-17-10-4-3-5-11-17)12-14-6-8-15(16)9-7-14;/h6-9H,3-5,10-13H2,1-2H3;1H
InChIKey
VGKGHWXDGBFJTP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Silperisone hydrochloride
CAS: 140944-30-5
CID: 178567
Formula: C15H25ClFNSi
MW: 301.90
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight301.90
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Exact Mass301.1428822
Monoisotopic Mass301.1428822
Topological Polar Surface Area3.2 Ų
Heavy Atom Count19
Formal Charge0
Complexity243
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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