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VT02956 (hydrochloride)

CAT: 0804-HY-147165ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147165ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VT02956 is a LATS inhibitor (IC50: 0.76 nM for LATS1, 0.52 nM for LATS2) . VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organoids[1]. VT02956 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
UNSPSC
12352005
Target
YAP
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vt02956-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
NCC1CCN(CC1)C2=NC(C3=CC=NC=C3)=NC4=C2C=CC=C4C#CCO.[H]Cl
Molecular Formula
C22H24ClN5O
Molecular Weight
409.91
References & Citations
[1]Ma S, et al. Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER+ breast cancer. Nat Commun. 2022 Feb 25;13 (1) :1061.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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