Penehyclidine (hydrochloride)

• UNSPSC Description:

  Penehyclidine (Penequinine) hydrochloride, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine hydrochloride activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine hydrochloride can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation[1].

• Target Antigen:

  mAChR; NF-κB

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling;NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/penehyclidine-hydrochloride.html

• Purity:

  99.2

• Solubility:

  H2O : 2 mg/mL (ultrasonic;warming)

• Smiles:

  OC(C1CCCC1)(COC2CN3CCC2CC3)C4=CC=CC=C4.[H]Cl

• Molecular Weight:

  351.91

• References & Citations:

  [1]Zhi-Yuan Chen, et al. The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation. Int J Chron Obstruct Pulmon Dis. 2021 Mar 31;16:877-885.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  Launched

• CAS Number:

  151937-76-7