Creatine

CAT: 0804-HY-W010388-03Size: 5 gDry Ice: NoHazardous: No

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CAT#:0804-HY-W010388-03Size:5 g

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Description

Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain.

CAS Number

57-00-1

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Dopamine Receptor; Endogenous Metabolite

Type

Natural Products

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-_1-Methylguanidino_acetic_acid.html

Concentration

10mM

Purity

99.95

Solubility

H2O : 6.25 mg/mL (ultrasonic)

Smiles

CN(C(N)=N)CC(O)=O

Molecular Formula

C4H9N3O2

Molecular Weight

131.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Nouioua S, et al. Creatine deficiency syndrome. A treatable myopathy due to arginine-glycine amidinotransferase (AGAT) deficiency. Neuromuscul Disord. 2013 Aug;23 (8) :670-4.|[2]Gerber I, et al., Stimulatory effects of creatine on metabolic activity, differentiation and mineralization of primary osteoblast-like cells in monolayer and micromass cell cultures. Eur Cell Mater. 2005 Jul 15;10:8-22. |[3]Guidi C, et al., Differential effect of creatine on oxidatively-injured mitochondrial and nuclear DNA. Biochim Biophys Acta. 2008 Jan;1780 (1) :16-26. |[4]Cunha MP, et al., Antidepressant-like effect of creatine in mice involves dopaminergic activation. J Psychopharmacol. 2012 Nov;26 (11) :1489-501.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

Human Endogenous Metabolite; Microbial Metabolite

Chemical Information

Creatine

Creatine is a glycine derivative having methyl and amidino groups attached to the nitrogen. It has a role as a geroprotector, a nutraceutical, a neuroprotective agent, a mouse metabolite and a human metabolite. It is a glycine derivative and a member of guanidines. It is a conjugate acid of a creatinate. It is a tautomer of a creatine zwitterion.

CAS Number	57-00-1
PubChem CID	586
IUPAC Name	2-[carbamimidoyl(methyl)amino]acetic acid
Molecular Formula	C4H9N3O2
Molecular Weight	131.13
XLogP	-1.2
Topological Polar Surface Area	90.4
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Heavy Atom Count	9
Formal Charge	0
Complexity	134

SMILES

CN(CC(=O)O)C(=N)N

InChI

InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9)

InChIKey

CVSVTCORWBXHQV-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 57-00-1

CID: 586

Formula: C4H9N3O2

MW: 131.13

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	131.13
XLogP3	-1.2
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	131.069476538
Monoisotopic Mass	131.069476538
Topological Polar Surface Area	90.4 Å²
Heavy Atom Count	9
Formal Charge	0
Complexity	134
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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C6421-100	Creatine monohydrate
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Chemical Information

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