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CREBtide (TFA)

CAT: 0804-HY-P1595A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1595A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CREBtide TFA is a CREB (cAMP response element binding protein) -like peptide. CREBtide TFA a synthetic 13 amino acid peptide, has been reported as a PKA and PKC substrate[1][2][3].
UNSPSC
12352209
Target
PKA; PKC
Type
Peptides
Related Pathways
Epigenetics; Stem Cell/Wnt; TGF-beta/Smad
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/crebtide-tfa.html
Purity
98.72
Solubility
H2O
Smiles
NCCCC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@@H](CC2=CC=C(O)C=C2)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)CO)=O)CCC1)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CO)=O)CC(C)C)=O)[C@H](CC)C)=O)CCC(O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)N.O=C(C(F)(F)F)O.[x]
Molecular Formula
C73H129N29O19.xC2HF3O2
Molecular Weight
1716.99 (free acid)
References & Citations
[1]Wu J, et al. A microPLC-based approach for determining kinase-substrate specificity. Assay Drug Dev Technol. 2007 Aug;5 (4) :559-66.|[2]Colbran JL, et al. cAMP-dependent protein kinase, but not the cGMP-dependent enzyme, rapidly phosphorylates delta-CREB, and a synthetic delta-CREB peptide. Biochem Cell Biol. 1992 Oct-Nov;70 (10-11) :1277-82.|[3]Harum KH, et al. Cognitive impairment in Coffin-Lowry syndrome correlates with reduced RSK2 activation. Neurology. 2001 Jan 23;56 (2) :207-14.|[4]Peng J, et al. Protein kinase C-α signals P115RhoGEF phosphorylation and RhoA activation in TNF-α-induced mouse brain microvascular endothelial cell barrier dysfunction. J Neuroinflammation. 2011 Apr 8;8:28.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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