Creatine

• Description :

  Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain.

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Dopamine Receptor; Endogenous Metabolite

• Type :

  Natural Products

• Related Pathways :

  GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Cancer; Metabolic Disease; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/2-_1-Methylguanidino_acetic_acid.html

• Concentration :

  10mM

• Purity :

  99.95

• Solubility :

  H2O : 6.25 mg/mL (ultrasonic)

• Smiles :

  CN(C(N)=N)CC(O)=O

• Molecular Formula :

  C4H9N3O2

• Molecular Weight :

  131.13

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Nouioua S, et al. Creatine deficiency syndrome. A treatable myopathy due to arginine-glycine amidinotransferase (AGAT) deficiency. Neuromuscul Disord. 2013 Aug;23 (8) :670-4.|[2]Gerber I, et al., Stimulatory effects of creatine on metabolic activity, differentiation and mineralization of primary osteoblast-like cells in monolayer and micromass cell cultures. Eur Cell Mater. 2005 Jul 15;10:8-22. |[3]Guidi C, et al., Differential effect of creatine on oxidatively-injured mitochondrial and nuclear DNA. Biochim Biophys Acta. 2008 Jan;1780 (1) :16-26. |[4]Cunha MP, et al., Antidepressant-like effect of creatine in mice involves dopaminergic activation. J Psychopharmacol. 2012 Nov;26 (11) :1489-501.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• Isoform :

  Human Endogenous Metabolite; Microbial Metabolite

• CAS Number :

  [57-00-1]