B-Raf IN 1

B-Raf IN 1

• CAS Number: 950736-05-7
• UNSPSC Description: B-Raf IN 1 is a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM.
• Target Antigen: Raf
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/B-Raf-IN-1.html
• Purity: 99.94
• Solubility: DMSO : 65 mg/mL (ultrasonic)
• Smiles: O=C(NC1=CC=CC(C2=CC=NC3=C(C4=CC=C(CN(C)C)C=C4)C=NN23)=C1)C5=CC=CC(C(F)(F)F)=C5
• Molecular Weight: 515.53
• References & Citations: [1]Berger DM, et al. Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported