Autophagy-IN-1

Autophagy-IN-1

• CAS Number: 3031485-19-2
• UNSPSC Description: Autophagy-IN-1 is a potent autophagy/mitophagy inhibitor, acts by selectively increasing the autophagic flux while blocking the autophagosome-lysosome fusion in cancer cells. Autophagy-IN-1 can induce apoptosis and cell cycle arrest. Autophagy-IN-1 significantly inhibits tumor growth in an HCT116 xenograft mouse model and with low toxicity. Autophagy-IN-1 can be used for researching colorectal cancer[1].
• Target Antigen: Apoptosis; Autophagy
• Type: Reference compound
• Related Pathways: Apoptosis;Autophagy
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/autophagy-in-1.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C1O[C@@H](O/C=C([C@@H]2CC3=CC=C4NC(OC(C)(C)C)=O)/C(O[C@H]2C3=C4)=O)C(C)=C1C
• Molecular Weight: 427.45
• References & Citations: [1]Yang ST, et al. Development of Strigolactones as Novel Autophagy/Mitophagy Inhibitors against Colorectal Cancer Cells by Blocking the Autophagosome-Lysosome Fusion. J Med Chem. 2022 Jul 19.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported