Autophagy/REV-ERB-IN-1

• UNSPSC Description:

  Autophagy/REV-ERB-IN-1 (compound 24) is a dual inhibitor of autophagy and REV-ERB. Autophagy/REV-ERB-IN-1 has anti-tumor activity with a CC50 value of 2.3 μM on BTB-474 cells.

• Target Antigen:

  Autophagy; REV-ERB

• Type:

  Reference compound

• Related Pathways:

  Autophagy;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/autophagy-rev-erb-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=CC=C(C2(NCC3=CC=C(F)C(CC4CCNCC4)=C3)CCCC2)C=C1

• Molecular Weight:

  384.51

• References & Citations:

  [1]Martina Palomba, et al. Identification of a Dual Autophagy and REV-ERB Inhibitor with in Vivo Anticancer Efficacy. J Med Chem. 2024, 67, 1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported