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RN-9893 (hydrochloride)

CAT: 0931-T37321Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T37321Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2109450-40-8
Target
TRP/TRPV Channel, Others
Related Pathways
Others, Membrane transporter/Ion channel
Bioactivity
RN-9893 is an antagonist of transient receptor potential vanilloid 4 (TRPV4; IC50s = 0.42 and 0.66 μM, respectively, for the human and rat receptors) .1 It is selective for TRPV4 over TRPV1, TRPV3, and TRPM8 (IC50s = 10, >30, and 30 μM, respectively) . RN-9893 reduces rat TRPV4 activity induced by 4α-phorbol 12,13-didecanoate or hypotonicity (IC50s = 0.57 and 2.1 μM, respectively, in cell free assays) .
Smiles
Cl.O=C(NC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C(C)C)C3=CC=C(C=C3N(=O)=O)C(F)(F)F
Molecular Formula
C21H24ClF3N4O5S
Molecular Weight
536.95
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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