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SPAST rabbit pAb

CAT: 0855-ES12999-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES12999-01Size:50 µL
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Background
This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4. [provided by RefSeq, Jul 2008]
Description
This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4. [provided by RefSeq, Jul 2008],
UniProt
Q9UBP0
Swiss Prot
Q9UBP0
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human SPAST AA range: 163-213
Target
SPAST
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Membrane ; Peripheral membrane protein . Endoplasmic reticulum . Midbody . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton . Cytoplasm, perinuclear region . Nucleus . Cytoplasm, cytoskeleton, spindle . Cytoplasm . Forms an intramembrane hairpin-like structure in the membrane (PubMed:20200447) . Localization to the centrosome is independent of microtubules (PubMed:15891913) . Localizes to the midbody of dividing cells, and this requires CHMP1B (PubMed:18997780) . Enriched in the distal axons and branches of postmitotic neurons (PubMed:15269182) . .; [Isoform 1]: Endoplasmic reticulum membrane ; Peripheral membrane protein . Nucleus membrane . Lipid droplet . Cytoplasm, cytoskeleton . Endosome . Forms an intramembrane hairpin-like structure in the mem
Gene ID (Human)
6683

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