MMP-9/10-IN-1

MMP-9/10-IN-1

• UNSPSC Description: MMP-9/10-IN-1 (Compound 6b) is a potent dual MMP-9/10 Inhibotor with IC50s of 0.076 and 0.139 μM against NSCLC and A549 cells, respectively. MMP-9/10-IN-1 has anti-invasive and anti-angiogenic activities when in combination with Sorafenib (HY-10201) [1].
• Target Antigen: MMP
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mmp-9-10-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CC=C(NC(N=C(O)N2)=NC2=O)C=C1)NC3=CC=C(Cl)C=C3
• Molecular Weight: 357.75
• References & Citations: [1]Khalil HH, et al. Chemosensitization of non-small cell lung cancer to sorafenib via non-hydroxamate s-triazinedione-based MMP-9/10 inhibitors. Bioorg Chem. 2024 Mar;144:107155.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported