MMP-9/10-IN-1

• UNSPSC Description:

  MMP-9/10-IN-1 (Compound 6b) is a potent dual MMP-9/10 Inhibotor with IC50s of 0.076 and 0.139 μM against NSCLC and A549 cells, respectively. MMP-9/10-IN-1 has anti-invasive and anti-angiogenic activities when in combination with Sorafenib (HY-10201) [1].

• Target Antigen:

  MMP

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mmp-9-10-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC=C(NC(N=C(O)N2)=NC2=O)C=C1)NC3=CC=C(Cl)C=C3

• Molecular Weight:

  357.75

• References & Citations:

  [1]Khalil HH, et al. Chemosensitization of non-small cell lung cancer to sorafenib via non-hydroxamate s-triazinedione-based MMP-9/10 inhibitors. Bioorg Chem. 2024 Mar;144:107155.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported