MMP-2/9-IN-1

MMP-2/9-IN-1

• CAS Number: 2415311-84-9
• UNSPSC Description: MMP-2/9-IN-1 (Compound 4a) is a potent dual MMP-2 and MMP-9 inhibitor with IC50 values of 56 nM and 38 nM, respectively. MMP-2/9-IN-1 inhibits tumor growth, strongly induces cancer cell apoptosis, inhibits cell migration, and suppresses cell cycle progression leading to DNA fragmentation[1].
• Target Antigen: MMP
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mmp-2-9-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: C/C(C1=C(C)N=C(N/N=C/C2=CC=C(I)C=C2)S1)=N\NC(N)=N
• Molecular Weight: 441.29
• References & Citations: [1]Omar AM, et al. Novel molecular discovery of promising amidine-based thiazole analogues as potent dual Matrix Metalloproteinase-2 and 9 inhibitors: Anticancer activity data with prominent cell cycle arrest and DNA fragmentation analysis effects. Bioorg Chem. 2020 Aug;101:103992.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported