MRK-952

• Description:

  MRK-952, a chemical probe, is a NUDIX hydrolase inhibitor. NUDIX enzymes are involved in cellular metabolism and homeostasis, as well as mRNA processing[1].

• UNSPSC:

  12352101

• Target:

  DNA/RNA Synthesis

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Smiles:

  CN1C=NC2=C1C(N3CC[C@@]4(CCN(C4)C5=CC(Cl)=C(C=C5)C(F)(F)F)C3)=NC=N2

• Molecular Formula:

  C20H20ClF3N6

• Molecular Weight:

  436.86

• References & Citations:

  [1]Carreras-Puigvert J, et al. A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family. Nat Commun. 2017 Nov 16;8 (1) :1541.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported