Glucokinase activator 10

• Description :

  Glucokinase activator 10, a thiazole-based compound, is a liver-selective and orally active  glucokinase activator with an EC50 of 42 nM. Glucokinase activator 10 exhibits significant glucose lowering in acute diet-induced obese mouse oral glucose tolerance (OGTT) test. Glucokinase activator 10 can be used for the study of metabolic disorders[1].

• UNSPSC :

  12352005

• Target :

  Glucokinase

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Metabolic Disease

• Smiles :

  O=S(C1=CC=C(OC2=CC(C(NC3=NC(CCCOP(C)(C)=O)=CS3)=O)=CC(O[C@@H](C)COC)=C2)C=N1)(C)=O

• Molecular Formula :

  C25H32N3O8PS2

• Molecular Weight :

  597.64

• References & Citations :

  [1]Yoon DS, et al. Discovery of liver-selective glucokinase activators comprising N- (4-alkylthiazol-2-yl) benzamides and N- (3-alkyl-1,2,4-thiadiazol-5-yl) benzamides for the treatment of metabolic disorders. Bioorg Med Chem Lett. 2025 Jul 1;122:130192.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported