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Glucokinase activator 10

CAT: 0804-HY-179419Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179419Size:1 Each
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Description
Glucokinase activator 10, a thiazole-based compound, is a liver-selective and orally active  glucokinase activator with an EC50 of 42 nM. Glucokinase activator 10 exhibits significant glucose lowering in acute diet-induced obese mouse oral glucose tolerance (OGTT) test. Glucokinase activator 10 can be used for the study of metabolic disorders[1].
UNSPSC
12352005
Target
Glucokinase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
O=S(C1=CC=C(OC2=CC(C(NC3=NC(CCCOP(C)(C)=O)=CS3)=O)=CC(O[C@@H](C)COC)=C2)C=N1)(C)=O
Molecular Formula
C25H32N3O8PS2
Molecular Weight
597.64
References & Citations
[1]Yoon DS, et al. Discovery of liver-selective glucokinase activators comprising N- (4-alkylthiazol-2-yl) benzamides and N- (3-alkyl-1,2,4-thiadiazol-5-yl) benzamides for the treatment of metabolic disorders. Bioorg Med Chem Lett. 2025 Jul 1;122:130192.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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