HG-7-85-01-NH2

HG-7-85-01-NH2

• CAS Number: 1258391-29-5
• UNSPSC Description: HG-7-85-01-NH2 is the HG-7-85-01 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER[1].
• Target Antigen: Bcr-Abl; Ligands for Target Protein for PROTAC; SNIPERs
• Type: Reference compound
• Related Pathways: PROTAC;Protein Tyrosine Kinase/RTK
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hg-7-85-01-nh2.html
• Purity: 99.20
• Solubility: DMSO : 125 mg/mL (ultrasonic;adjust pH to 5 with H2O)
• Smiles: O=C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)C3=CC=CC(C4=CC=C5C(SC(N)=N5)=N4)=C3
• Molecular Weight: 540.60
• References & Citations: [1]Shibata N, et al. Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase. Sci Rep. 2018 Sep 10;8(1):13549.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported