Products for Research Use Only
RegisterLogin

GNE-049

CAT: 0804-HY-108435-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-108435-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
GNE-049 is a highly potent and selective CBP inhibitor with an IC50 of 1.1 nM in TR-FRET assay. GNE-049 also inhibits BRET and BRD4 (1) with IC50s of 12 nM and 4200 nM, respectively[1].
CAS Number
1936421-41-8
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Epigenetic Reader Domain; Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GNE-049.html
Concentration
10mM
Purity
99.33
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(N1CCC(N(C2CCOCC2)N=C3N4CCCC5=C4C=C(C(F)F)C(C6=CN(C)N=C6)=C5)=C3C1)=O
Molecular Formula
C27H32F2N6O2
Molecular Weight
510.58
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Romero FA, et al. GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) . J Med Chem. 2017 Nov 22;60 (22) :9162-9183.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300

Related Products

CatalogName
HY-111851SNIPER (ABL) -049
HY-142160-01GNE-9815
HY-108696-01GNE-781
HY-114332-01GNE-8505
HY-15882GNE-783
HY-126291GNE-616
HY-12947-01GNE-3511
HY-12632-01GNE 2861
HY-132294-01GNE-502
HY-120028-01GNE-207

Alternative Products

CatalogName
T15397-01GNE-049
A20206-25GNE-049 25mg
A20206-10GNE-049 10mg
A20206-5GNE-049 5mg
A20206-50GNE-049 50mg
A20206-100GNE-049 100mg
A20206-1GNE-049 1mg
T39352-01Piperidine-GNE-049-N-Boc

Popular Products