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Pentamidine

CAT: 1410-M22529-01Size: 1 EachDry Ice: NoHazardous: No
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Description
Pentamidine is an antifungal and antiprotozoal agent, interacting directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication.Pentamidine is effective in therapy for the hemolymphatic stage of Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia.
CAS Number
100-33-4
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
340.42
Molecular Formula
C19H24N4O2
Notes
Research use only, not for human use.
Receptor
Antifungal

100-33-4

PubChem
cas100-33-4
modify2026-05-17
descriptionPentamidine is a diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease. It has a role as a calmodulin antagonist, a S100 calcium-binding protein B inhibitor, a xenobiotic, an antifungal agent, a trypanocidal drug, a NMDA receptor antagonist, a chemokine receptor 5 antagonist, an anti-inflammatory agent and an EC 2.3.1.48 (histone acetyltransferase) inhibitor. It is a carboxamidine, an aromatic ether and a diether. It is a conjugate base of a pentamidinium(2+).
synonyms
pentamidine100-33-4Pentamidina4,4'-(Pentamethylenedioxy)dibenzamidinePentamidinPentamidinum4,4'-Diamidinodiphenoxypentanep,p'-(Pentamethylenedioxy)dibenzamidinePentam 300 (as isethionate)Nebupent (as isethionate)+ 15 more
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