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Pentamidine

CAT: 0931-T23133-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T23133-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
100-33-4
Target
Antifungal, Parasite, Phosphatase, Antibacterial, Antibiotic
Related Pathways
Metabolism, Microbiology/Virology
Purity
0.9967
Bioactivity
Pentamidine is an antifungal and antiprotozoal agent, interacting directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication.
Smiles
C(=N)(N)C1=CC=C(OCCCCCOC2=CC=C(C(=N)N)C=C2)C=C1
Molecular Formula
C19H24N4O2
Molecular Weight
340.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

100-33-4

PubChem
cas100-33-4
modify2026-05-17
descriptionPentamidine is a diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease. It has a role as a calmodulin antagonist, a S100 calcium-binding protein B inhibitor, a xenobiotic, an antifungal agent, a trypanocidal drug, a NMDA receptor antagonist, a chemokine receptor 5 antagonist, an anti-inflammatory agent and an EC 2.3.1.48 (histone acetyltransferase) inhibitor. It is a carboxamidine, an aromatic ether and a diether. It is a conjugate base of a pentamidinium(2+).
synonyms
pentamidine100-33-4Pentamidina4,4'-(Pentamethylenedioxy)dibenzamidinePentamidinPentamidinum4,4'-Diamidinodiphenoxypentanep,p'-(Pentamethylenedioxy)dibenzamidinePentam 300 (as isethionate)Nebupent (as isethionate)+ 15 more
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