Rapastinel (acetate)

CAT: 0804-HY-16728ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-16728ASize:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Rapastinel acetate (GLYX-13 acetate) is an N-methyl-D-aspartate (NMDA) receptor modulator with long-acting antidepressant activity. Rapastinel acetate exerts its antidepressant effects by enhancing long-term potentiation (LTP) of synaptic transmission. Rapastinel acetate transiently enhances NMDAR-mediated currents in pyramidal neurons in the hippocampus and medial prefrontal cortex by binding to unique sites on the NMDAR complex. Rapastinel acetate significantly enhanced NMDAR-mediated currents at a concentration of 1 μmol/l and significantly reduced the currents at a concentration of 10 μmol/l. The mechanism of action of Rapastinel acetate is related to the reduction of affinity to intracellular calcium inactivation sites, which provides a theoretical basis for enhancing conductance mediated by NMDAR[1].
CAS Number
[491872-39-0]
Product Name Alternative
GLYX-13 (acetate)
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rapastinel-acetate.html
Smiles
CC(O)=O.O=C(N(CCC1)[C@@H]1C(N[C@H](C(N)=O)[C@H](O)C)=O)[C@H](CCC2)N2C([C@@H](N)[C@H](O)C)=O
Molecular Formula
C20H35N5O8
Molecular Weight
473.52
References & Citations
[1]Burgdorf J, et al. The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus. Neuroscience. 2015 Nov 12;308:202-11.|[2]Extracellular application of the N-methyl-D-aspartate receptor allosteric modulator rapastinel acts remotely to regulate Ca2+ inactivation at an intracellular locus
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3

Related Products

CatalogName
HY-16728-01Rapastinel
HY-16728B-01Rapastinel (Trifluoroacetate)
HY-166875SApramycin acetate-d7 (acetate)
HY-134716Methyl acetate-PEG1-methyl acetate
HY-W127616-01β-Sitosterol acetate, 40% (contains Campesterol acetate)
HY-W289164Nonyl acetate
HY-W127561-01Oleyl acetate
HY-N9235Wilforlide A acetate
HY-B0137BPrilocaine (acetate)
HY-N13323Ylangenyl acetate

Alternative Products

CatalogName
MBS3616586-01Rapastinel acetate
326679Rapastinel
BUP12584-01Rapastinel Trifluoroacetate
S6907-5mgRapastinel (GLYX-13)
MBS384777-01GLYX-13 (Rapastinel)
A13576-50GLYX-13 (Rapastinel) 50mg
A13576-25GLYX-13 (Rapastinel) 25mg
A13576-1GLYX-13 (Rapastinel) 1mg
A13576-10mM-DGLYX-13 (Rapastinel) 10mM * 1mL in DMSO
MBS641115-01Vitamin A Acetate (Retinol Acetate, Retinyl Acetate)

Popular Products